Dejan Kulusevski will be with the Tottenham squad at Old Trafford in a supporting role, while De Zerbi confirms Micky van de Ven, Jan Paul van Hecke and James Maddison are all available.
The Premier League returns after a three week international break, and Mitch Fretton has selected Arsenal, Aston Villa and a Manchester United versus Tottenham angle among Saturday’s bets.
Both clubs arrive at Old Trafford with a combined seven points from 10 games, and neither manager can afford another defeat.
Bruno Fernandes criticised Manchester United for repeated away mistakes after a 2-0 loss to Hull City.
Hull City made a winning return to the Premier League by beating Manchester United 2-0, with first-half set-piece goals from Semi Ajayi and Nobel Mendy.
Bruno Fernandes blamed familiar failings as Manchester United lost 2-0 at Hull City, with goals from Semi Ajayi and Nobel Mendy.
Maguire wants Rashford to stay at Manchester United, calling him a ‘huge threat’ after his return in a 4-2 preseason defeat to AC Milan.
Samuel Chukwueze scored one goal and set up two others as AC Milan twice came from behind to beat Manchester United 4-2 in a preseason friendly.
Rashford’s comeback could not prevent Manchester United slipping to a 4-2 preseason loss to AC Milan in Wroclaw.
Former Arsenal striker Alan Smith rules out Chelsea and Manchester United from the title race, leaving only Arsenal and Manchester City.
